From channelopathies to clinical arrhythmias
- Förderkennzeichen
81Z2500201
- Projektnummer
464
- Institution
- Ruprecht-Karls-Universität Heidelberg
- Projektleiter
- Martin Borggrefe
- Standort
- Heidelberg/Mannheim
- Kurzbeschreibung
-
Investigation of underlying mechanisms and identification of new therapeutic targets: hiPSC-CMs possess characteristics similar to that of native human cardiomyocytes and can model the …
Investigation of underlying mechanisms and identification of new therapeutic targets: hiPSC-CMs possess characteristics similar to that of native human cardiomyocytes and can model the main features of some heart diseases. They provide a new platform to study the disease pathology and screen drugs. The aim of our study is to use the hiPSC-CMs modeling the arrhythmogenic heart diseases (SQTs, LQTs, Brugada syndrome, ARVC, HCM and DCM) for studying the underlying mechanisms and identifying new therapeutic targets for the treatment of the diseases. In addition, we will test effects of drugs on the diseased hiPSC-CMs and design better drug treatments for the diseases
- Projektart
- Standortprojekt
- Stichwörter
- iPS, arrhythmias, Patch-clamp
- Topic
- iPSC
- Fördersumme
- € 554.176,29
- Beginn
- 01.01.2015
- Ende
- 31.12.2018